Lithium citrate

Lithium citrate

Other names Trilithium citrate trilithium 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
CAS number	919-16-4^Y
ChemSpider	12932^Y
ChEMBL	CHEMBL1201170^N
RTECS number	TZ8616000
Jmol-3D images	Image 1
SMILES [Li+].[Li+].[Li+].O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-]
InChI InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3+1/p-3^Y Key: WJSIUCDMWSDDCE-UHFFFAOYSA-K^Y InChI=1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3+1/p-3 Key: WJSIUCDMWSDDCE-DFZHHIFOAV
Properties
Molecular formula	Li₃C₆H₅O₇
Molar mass	209.923 g mol⁻¹
Appearance	Odorless white powder
Melting point	decomposes at 105 °C
Hazards
R-phrases	R22 R36 R37 R38
Main hazards	Toxic
Flash point	N/A
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Lithium citrate (Li₃C₆H₅O₇) is a chemical compound of lithium and citrate that is used as a mood stabilizer in psychiatric treatment of manic states and bipolar disorder.^[1] For the medical aspects of lithium citrate, see lithium pharmacology.

Hundreds of soft drinks included lithium salts or lithia water (naturally occurring mineral waters with higher lithium amounts). An early version of Coca-Cola available in pharmacies' soda fountains called Lithia Coke was a mixture of Coca-Cola syrup and lithia water.^[2] The soft drink 7Up was originally named "Bib-Label Lithiated Lemon-Lime Soda" when it was formulated in 1929 because it contained lithium citrate. The beverage was a patent medicine marketed as a cure for hangover. Lithium citrate was removed from 7Up in 1948.^[3]

Lithium citrate is sold as Litarex and Demalit.

References

^ Medical use
^ And Now Lithium in Water
^ Gielen, Marcel; Edward R. T. Tiekink (2005). Metallotherapeutic drugs and metal-based diagnostic agents: The use of metals in medicine. John Wiley and Sons. p. 3. ISBN 0470864036.

Mood stabilizers

Carbamazepine • Divalproex sodium • Gabapentin • Lamotrigine • Licarbazepine • Lithium • Omega-3 fatty acids • Oxcarbazepine • Pregabalin • Sodium valproate • Tiagabine • Topiramate • Valproic acid

Mood disorder (F30–F39, 296)

History

Emil Kraepelin · Karl Leonhard · John Cade · Mogens Schou · Frederick K. Goodwin · Kay Redfield Jamison

Symptoms

Hallucination · Delusion · Emotional dysregulation (Anhedonia, Dysphoria, Suicidal ideation) · sleep disorder (Hypersomnia, Insomnia) · Psychosis · Racing thoughts

Spectrum

Bipolar disorder (Bipolar I, Bipolar II, Bipolar NOS) · Cyclothymia · Dysthymia · Major depressive disorder · Schizoaffective disorder

Mania · Mixed state · Hypomania · Major depressive episode · Rapid cycling

Treatment

Anticonvulsants	Carbamazepine · Gabapentin · Lamotrigine · Oxcarbazepine · Topiramate · Valproic acid (Sodium valproate, Valproate semisodium)

Other mood stabilizers	Lithium pharmacology (Lithium carbonate, Lithium citrate, Lithium sulfate) · Antipsychotics

Non-pharmaceutical	Clinical psychology · Electroconvulsive therapy · Involuntary commitment · Light therapy · Psychotherapy · Transcranial magnetic stimulation · Cognitive behavioral therapy

Affective spectrum · List of people affected by bipolar disorder · Bipolar disorder in children · Book:Bipolar Disorder

M: PSO/PSI

mepr

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)

Lithium compounds

Inorganic	LiAlH₄ LiAlO₂ LiBF₄ LiBH₄ LiBO₂ LiB₃O₅ LiBr LiCl LiClO LiClO₃ LiClO₄ LiCoO₂ LiF LiH LiI LiNH₂ LiNO₃ LiNbO₃ LiOH LiO₂ LiPF₆ LiTaO₃ Li₂B₄O₇ Li₂CO₃ Li₂C₂ Li₂MoO₄ Li₂O Li₂O₂ Li₂S Li₂SO₄ Li₃N

Organic	acetate citrate diisopropylamide orotate succinate organolithiums

Minerals	Amblygonite Elbaite Eucryptite Jadarite Lepidolite Lithiophilite Petalite Pezzottaite Saliotite Spodumene Sugilite Tourmaline Zabuyelite Zinnwaldite